Endocrine Abstracts

Psoriasis (PS) is a skin disease of immune T-cell mediated. It is well known that obesity is a risk factor for severity PS and PS is associated with the degree of overweight. In addition, patients with PS have increased risk of metabolic disorders such as diabetes mellitus (DM) and dyslipidaemia. All these processes are characterised by the presence of systemic chronic inflammation. Liraglutide, an agonist receptor GLP-1, is being used in the treatment of obesity and diabetes ...

Nesfatin-1, product of the precursor NEFA/nucleobindin 2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner. In addition to its central role in the control of energy homeostasis, evidence has mounted recently that nesfatin-1 is also produced in peripheral metabolic tissues, such as pancreas, adipose and gut. Moreover, nesfatin-1 has been shown to participate in the control of body functions gated by whole-body energy...

Craniopharyngiomas (CP) are low-prevalent tumors characterized for their local invasiveness and poor clinical outcomes, often requiring aggressive therapeutic measures. Ki67 is a marker of proliferation with good correlation with tumor recurrence in many solid tumors but this relationship is unclear in CP. Our aim is to determine whether Ki67 could be a marker for recurrence in CP.Material and methods: Descriptive retrospective observational study. All p...

Introduction: Immunotherapy is the oncological treatment whose objective seeks, through the use of immunomodulatory monoclonal antibodies, to block the regulation of the activation and response of T cells, increasing their antitumor response. Pembrolizumab is a new monoclonal antibody directed against the surface protein PD 1, (Programmed Cell Death-1), responsible for the inhibition of the immune response, mediated by T cells, against cancer cells; indicated in the treatment ...

Background: Acquired hypoparathyroidism due to thyroid surgery for thyroid cancer is the most common postsurgical etiology in a tertiary health center in Ecuador. Therefore, the data published from our country is limited. An observational cross-sectional study was carried out to determine the clinical, biochemical and therapeutic characteristics of patients with permanent hypoparathyroidism in the endocrinology department.Results: 102 patients were inclu...

Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It has been defined by an absence of overt Cushing’s syndrome (CS) signs (no skin weakness, muscle atrophy, or osteoporosis) associated with biological hypercortisolism consisting of high urinary free cortisol (UFC) and an absence of negative feedback loop of cortisol on HPA, defined as 8-AM cortisol level >50 n...

Introduction: Hypoaldosteronism can be induced by a deficit of aldosterone production (AldDef) or a mineralocorticoid resistance (MinRes). Experts have proposed to use hyperkalemia-based aldosterone values for this purpose. However, there is no a range of aldosterone values indicating one of this type of hypoaldosteronism. In 2008, Adam W. R.1 hypothesized that the factored aldosterone (FAldo) could be useful differentiating hypoaldosteronism secondary to MinRes fro...

Background : Obesity is a chronic and complex health problem. Although it is a preventable health risk factor, it´s prevalence has grown rapidly in recent years. There are studies that demonstrate the relationship between hyperprolactinemia and obesity. However, it is not well explained and the results are contradictory. The objective of this study was to evaluate the relationship between increased prolactin and Body Mass Index (BMI) in patients with pituitary macroadenom...

Kiss1 neurons are essential elements in the central pathways controlling the reproductive axis. In rodents, two major hypothalamic populations of Kiss1 neurons exist, in the arcuate nucleus (ARC) and in the rostral periventricular area of the third ventricle (RP3V). The majority of ARC Kiss1 neurons express two others neuropeptides, neurokinin B (NKB; encoded by Tac2) and dynorphin (Dyn); hence, this population has been named KNDy. Yet, NKB-only and Kiss1-only neurons are also...

Purpose: Non-Obstructive Azoospermia (NOA), occurring in approximately 1% of men, has an unknown etiology in the majority of cases. This study aims at evaluating the diagnostic efficiency of a gene panel contemplating all known genes associated with azoospermia in mice.Subjects and methods: Design of a ‘mouse azoospermia’ gene panel through the consultation of MGI; selection of 175 mouse azoospermia genes with human orthologues; selection of 31...